Antisense Publications

Preclinical and clinical experience of antisense therapy for solid tumors.
Webb MS, Zon G.
Curr Opin Mol Ther. 1999 Aug;1(4):458-63. Review.

Safety of intracoronary administration of c-myc antisense oligomers after percutaneous transluminal coronary angioplasty (PTCA).
Roqué F, Mon G, Belardi J, Rodriguez A, Grinfeld L, Long R, Grossman S, Malcolm A, Zon G, Ormont ML, Fischman DL, Shi Y, Zalewski A.
Antisense Nucleic Acid Drug Dev. 2001 Apr;11(2):99-106.

Enhanced anti-tumor effects with microencapsulated c-myc antisense oligonucleotide.
Putney SD, Brown J, Cucco C, Lee R, Skorski T, Leonetti C, Geiser T, Calabretta B, Zupi G, Zon G.
Antisense Nucleic Acid Drug Dev. 1999 Oct;9(5):451-8.

c-myc antisense oligodeoxynucleotides enhance the efficacy of cisplatin in melanoma chemotherapy in vitro and in nude mice.
Citro G, D’Agnano I, Leonetti C, Perini R, Bucci B, Zon G, Calabretta B, Zupi G.
Cancer Res. 1998 Jan 15;58(2):283-9.

Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice.
Skorski T, Nieborowska-Skorska M, Wlodarski P, Zon G, Iozzo RV, Calabretta B.
Blood. 1996 Aug 1;88(3):1005-12.

Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo.
Del Bufalo D, Cucco C, Leonetti C, Citro G, D’Agnano I, Benassi M, Geiser T, Zon G, Calabretta B, Zupi G.
Br J Cancer. 1996 Aug;74(3):387-93.

B-cell proliferation and differentiation in common variable immunodeficiency patients produced by an antisense oligomer to the rev gene of HIV-1.
Branda RF, Moore AL, Hong R, McCormack JJ, Zon G, Cunningham-Rundles C.
Clin Immunol Immunopathol. 1996 May;79(2):115-21.

Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and and in mice.
Leonetti C, D’Agnano I, Lozupone F, Valentini A, Geiser T, Zon G, Calabretta B, Citro G C, Zupi G.
J Natl Cancer Inst. 1996 Apr 3;88(7):419-29.

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.
Bishop MR, Iversen PL, Bayever E, Sharp JG, Greiner TC, Copple BL, Ruddon R, Zon G, Spinolo J, Arneson M, Armitage JO, Kessinger A.
J Clin Oncol. 1996 Apr;14(4):1320-6.

Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study.
de Serres M, McNulty MJ, Christensen L, Zon G, Findlay JW.
Anal Biochem. 1996 Jan 15;233(2):228-33.

An in vitro messenger RNA binding assay as a tool for identifying hybridization-competent antisense oligonucleotides.
Stull RA, Zon G, Szoka FC Jr.
Antisense Nucleic Acid Drug Dev. 1996 Fall;6(3):221-8.

Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Matsukura M, Koike K, Zon G.
Toxicol Lett. 1995 Dec;82-83:435-8.

Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes.
Skorski T, Nieborowska-Skorska M, Campbell K, Iozzo RV, Zon G, Darzynkiewicz Z, Calabretta B.
J Exp Med. 1995 Dec 1;182(6):1645-53.

Block of AIDS-Kaposi’s sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.
Ensoli B, Markham P, Kao V, Barillari G, Fiorelli V, Gendelman R, Raffeld M, Zon G, Gallo RC.
J Clin Invest. 1994 Nov;94(5):1736-46.

Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms.
Zelphati O, Imbach JL, Signoret N, Zon G, Rayner B, Leserman L.
Nucleic Acids Res. 1994 Oct 11;22(20):4307-14.

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.
Skorski T, Nieborowska-Skorska M, Nicolaides NC, Szczylik C, Iversen P, Iozzo RV, Zon G, Calabretta B.
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4504-8.

Biologic and therapeutic significance of MYB expression in human melanoma.
Hijiya N, Zhang J, Ratajczak MZ, Kant JA, DeRiel K, Herlyn M, Zon G, Gewirtz AM.
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4499-503.

Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion.
Iversen PL, Mata J, Tracewell WG, Zon G.
Antisense Res Dev. 1994 Spring;4(1):43-52.

HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.
Pirruccello SJ, Perry GA, Bock PJ, Lang MS, Noel SM, Zon G, Iversen PL.
Antisense Res Dev. 1994 Winter;4(4):285-9.

Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.
Li G, Lisziewicz J, Sun D, Zon G, Daefler S, Wong-Staal F, Gallo RC, Klotman ME.
J Virol. 1993 Nov;67(11):6882-8.

Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages.
Perno CF, Bergamini A, Pesce CD, Milanese G, Capozzi M, Aquaro S, Thaisrivongs S, Tarpley WG, Zon G, D’Agostini C, et al.
J Infect Dis. 1993 Nov;168(5):1148-56.

In vitro evaluation of phosphorothioate oligonucleotides targeted to the E2 mRNA of papillomavirus: potential treatment for genital warts.
Cowsert LM, Fox MC, Zon G, Mirabelli CK.
Antimicrob Agents Chemother. 1993 Feb;37(2):171-7.

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.
Ratajczak MZ, Kant JA, Luger SM, Hijiya N, Zhang J, Zon G, Gewirtz AM.
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11823-7.

Comparative inhibition of ras p21 protein synthesis with phosphorus-modified antisense oligonucleotides.
Chang EH, Yu Z, Shinozuka K, Zon G, Wilson WD, Strekowska A.
Anticancer Drug Des. 1989 Oct;4(3):221-32.

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.
Matsukura M, Zon G, Shinozuka K, Robert-Guroff M, Shimada T, Stein CA, Mitsuya H, Wong-Staal F, Cohen JS, Broder S.
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4244-8.

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
Matsukura M, Shinozuka K, Zon G, Mitsuya H, Reitz M, Cohen JS, Broder S.
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7706-10.

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.
Marcus-Sekura CJ, Woerner AM, Shinozuka K, Zon G, Quinnan GV Jr.
Nucleic Acids Res. 1987 Jul 24;15(14):5749-63.

RNA Interference (RNAi) Publications

Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system.
Pirollo KF, Rait A, Zhou Q, Hwang SH, Dagata JA, Zon G, Hogrefe RI, Palchik G, Chang EH.
Cancer Res. 2007 Apr 1;67(7):2938-43.

Chemically modified short interfering hybrids (siHYBRIDS): nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2.
Hogrefe RI, Lebedev AV, Zon G, Pirollo KF, Rait A, Zhou Q, Yu W, Chang EH.
Nucleosides Nucleotides Nucleic Acids. 2006;25(8):889-907.

Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery.
Pirollo KF, Zon G, Rait A, Zhou Q, Yu W, Hogrefe R, Chang EH.
Hum Gene Ther. 2006 Jan;17(1):117-24.

Modified Oligonucleotide Publications

Hot start PCR with heat-activatable primers: a novel approach for improved PCR performance.
Lebedev AV, Paul N, Yee J, Timoshchuk VA, Shum J, Miyagi K, Kellum J, Hogrefe RI, Zon G.
Nucleic Acids Res. 2008 Nov;36(20):e131. doi: 10.1093/nar/gkn575. Epub 2008 Sep 16.

Comparison of binding of N3′–>P5′ phosphoramidate and phosphorothioate oligonucleotides to cell surface proteins of cultured cells.
Hawley P, Nelson JS, Fearon KL, Zon G, Gibson I.
Antisense Nucleic Acid Drug Dev. 1999 Feb;9(1):61-9.

The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequence.
Wilson WD, Mizan S, Tanious FA, Yao S, Zon G.
J Mol Recognit. 1994 Jun;7(2):89-98. Review.

Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET).
Sixou S, Szoka FC Jr, Green GA, Giusti B, Zon G, Chin DJ.
Nucleic Acids Res. 1994 Feb 25;22(4):662-8.

Stabilities of duplexes and triplexes of dA19 + dT19 with alternating methylphosphonate and phosphodiester linkages.
Kibler-Herzog L, Zon G, Whittier G, Mizan S, Wilson WD.
Anticancer Drug Des. 1993 Feb;8(1):65-79.

Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers.
Kibler-Herzog L, Zon G, Uznanski B, Whittier G, Wilson WD.
Nucleic Acids Res. 1991 Jun 11;19(11):2979-86.

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.
Chin DJ, Green GA, Zon G, Szoka FC Jr, Straubinger RM.
New Biol. 1990 Dec;2(12):1091-100.

Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.
Kibler-Herzog L, Kell B, Zon G, Shinozuka K, Mizan S, Wilson WD.
Nucleic Acids Res. 1990 Jun 25;18(12):3545-55.

Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2.
Bower M, Summers MF, Powell C, Shinozuka K, Regan JB, Zon G, Wilson WD.
Nucleic Acids Res. 1987 Jun 25;15(12):4915-30.

Synthesis and characterization of oligodeoxyribonucleotides containing terminal phosphates. NMR, UV spectroscopic and thermodynamic analysis of duplex formation of [d(pGGAATTCC)]2, [d(GGAATTCCp)]2 and [d(pGGAATTCCp)]2.
Bower M, Summers MF, Kell B, Hoskins J, Zon G, Wilson WD.
Nucleic Acids Res. 1987 Apr 24;15(8):3531-47.

NMR studies of backbone-alkylated DNA: duplex stability, absolute stereochemistry, and chemical shift anomalies of prototypal isopropyl phosphotriester modified octanucleotides, (Rp,Rp)- and (Sp,Sp)-(d-[GGA(iPr)ATTCC])2 and -(d-[GGAA(iPr)TTCC])2.
Lawrence DP, Chen WQ, Zon G, Stec WJ, Uznanski B, Broido MS.
J Biomol Struct Dyn. 1987 Apr;4(5):757-83.

Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates.
LaPlanche LA, James TL, Powell C, Wilson WD, Uznanski B, Stec WJ, Summers MF, Zon G.
Nucleic Acids Res. 1986 Nov 25;14(22):9081-93.

Alkyl phosphotriester modified oligodeoxyribonucleotides. VI. NMR and UV spectroscopic studies of ethyl phosphotriester (Et) modified Rp-Rp and Sp-Sp duplexes, (d[GGAA(Et)TTCC])2.
Summers MF, Powell C, Egan W, Byrd RA, Wilson WD, Zon G.
Nucleic Acids Res. 1986 Sep 25;14(18):7421-36.

Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and stereospecific ethylation-interference studies.
Gallo KA, Shao KL, Phillips LR, Regan JB, Koziolkiewicz M, Uznanski B, Stec WJ, Zon G.
Nucleic Acids Res. 1986 Sep 25;14(18):7405-20.

Reversed-phase high-performance liquid chromatographic separation of diastereomeric phosphorothioate analogues of oligodeoxyribonucleotides and other backbone-modified congeners of DNA.
Stec WJ, Zon G, Uznanski B.
J Chromatogr. 1985 Jun 19;326:263-80.

Epigenetic Publications

Formamide as a denaturant for bisulfite conversion of genomic DNA: Bisulfite sequencing of the GSTPi and RARbeta2 genes of 43 formalin-fixed paraffin-embedded prostate cancer specimens.
Zon G, Barker MA, Kaur P, Groshen S, Jones LW, Imam SA, Boyd VL.
Anal Biochem. 2009 Sep 15;392(2):117-25. doi: 10.1016/j.ab.2009.06.001. Epub 2009 Jun 6.

Preparation of genome-wide DNA fragment libraries using bisulfite in polyacrylamide gel electrophoresis slices with formamide denaturation and quality control for massively parallel sequencing by oligonucleotide ligation and detection.
Ranade SS, Chung CB, Zon G, Boyd VL.
Anal Biochem. 2009 Jul 15;390(2):126-35. doi: 10.1016/j.ab.2009.04.020. Epub 2009 Apr 18.

Capillary electrophoretic analysis of methylation status in CpG-rich regions by single-base extension of primers modified with N6-methoxy-2,6-diaminopurine.
Boyd VL, Zon G.
Anal Biochem. 2008 Sep 1;380(1):13-20. doi: 10.1016/j.ab.2008.05.017. Epub 2008 May 20.

Methylation-dependent fragment separation: novel analysis of 5-methyl cytosine by capillary electrophoresis of amplified DNA using PCR incorporation of chemically modified dCTP.
Boyd VL, Moody KI, Karger AE, Livak KJ, Zon G, Burns JW.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):629-34.

Methylation-dependent fragment separation: direct detection of DNA methylation by capillary electrophoresis of PCR products from bisulfite-converted genomic DNA.
Boyd VL, Moody KI, Karger AE, Livak KJ, Zon G, Burns JW.
Anal Biochem. 2006 Jul 15;354(2):266-73. Epub 2006 May 6.

Bisulfite conversion of genomic DNA for methylation analysis: protocol simplification with higher recovery applicable to limited samples and increased throughput.
Boyd VL, Zon G.
Anal Biochem. 2004 Mar 15;326(2):278-80. No abstract available.