RNA in DNA—Mistake or Mystery?

  • Human DNA Misincorporates >1,000,000 Ribonucleotides Per Replication Cycle
  • These Mistakes are Likely Biological Mysteries
  • Four New Sequencing Methods May Demystify Why There’s “R in DNA”

When I came across a publication on the presence of RNA in DNA my initial reaction, frankly, was great surprise, if not outright disbelief. As the so-called “blueprint” of life, I reckoned that DNA is virtually sacred in terms of its chemical composition, albeit subject to base mutations as well as insertions and deletions of sequence. In other words, I had heretofore been under the impression that DNA’s repeating units are 100% deoxyribonucleotide (and conversely that RNA’s are ribonucleotides), thus giving DNA (and RNA) the eponymous name is has. So, I thought to myself, if that’s reportedly not the case for DNA, what are the facts and implications, i.e., is RNA in DNA just a rare “mistake” or is this yet another example of a “mystery” of Nature. Below is what I’ve learned about this revelation.
Continue reading